A Review on Multiple Compressed Tablets

Multiple compressed tablets are compressed tablets made by more than one compression cycle. They are usually prepared to separate physically or chemically incompatible ingredients or to produce repeat or prolong action of drug. Compression coating perform similar functions as sugar or film coating except consists of dry coating concept hence prevents certain drawbacks of aqueous and non aqueous solvents used in sugar and film coating. There are three categories under this class: Compression coated tablets, Inlay tablets and Layered tablets. Multiple compression tablets, especially layered tablets, tend to solve incompatibility issues between two or more active pharmaceutical ingredients (APIs). Bilayer tablet provides adequate surface separation of two reactive ingredients but there may be some reactivity at the interface. If complete physical separation is required for stability purposes then three layered tablet may be employed.